Epistasis and pleiotropy constrain the evolution of cross-reactive breadth in a broadly neutralizing influenza antibody…
Epistasis and pleiotropy constrain the evolution of cross-reactive breadth in a broadly neutralizing influenza antibody A recent study investigates why the broadly neutralizing influenza antibody CR9114 remains unique in its ability to cross-react with both influenza A and B viruses, unlike other hemagglutinin stem-targeted antibodies. Researchers utilized deep mutational scanning and Tite-Seq…
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